About Bone Building

Let’s talk a little about anabolic medications like TYMLOS. Many osteoporosis treatments are antiresorptives, which slow down bone loss. TYMLOS is an anabolic medication. This kind of medication is designed to help boost the process that builds new bone.

How osteoporosis develops in women after menopause

For most of our lives, our bones go through a remodeling process. This means that our bodies are constantly breaking down old bone and forming new, healthy bone.

For women, estrogen helps regulate the bone remodeling process. However, estrogen levels decline after menopause, causing women to lose bone more quickly. This imbalance in the bone remodeling process can lead to osteoporosis.

How bone building works

TYMLOS is an anabolic medication. Anabolic medications may help boost your body’s natural bone-building process by activating cells called osteoblasts. These are the cells that normally form new, healthy bone through the remodeling process. With these medications, these cells work harder to replace the bone you’ve lost to osteoporosis and may help reduce your risk for future fractures.

Bone building process

BONE RESORPTION

Osteoclasts break down and remove old bone (resorption).

BONE FORMATION

Osteoblasts form new bone to replace the bone lost through resorption.

When you have osteoporosis, your body doesn’t form enough new bone to replace what is being broken down. This leaves bones fragile and at greater risk for fracture.

Bone density and T-scores

Bone mineral density (BMD) refers to the amount of bone mineral in your bones. If your bones are less dense, they are more fragile. Women with osteoporosis generally have low bone density.

When your doctor measures your BMD, you will get a T-score, which compares your BMD with the average BMD of young adults.

T-score What it means
-1 and above Normal
-2.5 to -1 Osteopenia, or low bone mass
Less than -2.5 Osteoporosis
Less than -2.5 and a fracture Severe osteoporosis

This image represents a bone with a T-score of

t-score-1

This image represents a bone with a T-score of

t-score-2

What is the most important information I should know about TYMLOS? Read more

TYMLOS may cause serious side effects including: Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more

What is the most important information I should know about TYMLOS?

TYMLOS may cause serious side effects including: Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more

What is the most important information I should know about TYMLOS?

  • Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more