About Bone Building
Let’s talk a little about anabolic medications like TYMLOS. Many osteoporosis treatments are antiresorptives, which slow down bone loss. TYMLOS is an anabolic medication. This kind of medication is designed to help boost the process that builds new bone.
How osteoporosis develops in women after menopause
For most of our lives, our bones go through a remodeling process. This means that our bodies are constantly breaking down old bone and forming new, healthy bone.
For women, estrogen helps regulate the bone remodeling process. However, estrogen levels decline after menopause, causing women to lose bone more quickly. This imbalance in the bone remodeling process can lead to osteoporosis.
How bone building works
TYMLOS is an anabolic medication. Anabolic medications may help boost your body’s natural bone-building process by activating cells called osteoblasts. These are the cells that normally form new, healthy bone through the remodeling process. With these medications, these cells work harder to replace the bone you’ve lost to osteoporosis and may help reduce your risk for future fractures.
Bone building process
Osteoclasts break down and remove old bone (resorption).
Osteoblasts form new bone to replace the bone lost through resorption.
When you have osteoporosis, your body doesn’t form enough new bone to replace what is being broken down. This leaves bones fragile and at greater risk for fracture.
Bone density and T-scores
Bone mineral density (BMD) refers to the amount of bone mineral in your bones. If your bones are less dense, they are more fragile. Women with osteoporosis generally have low bone density.
When your doctor measures your BMD, you will get a T-score, which compares your BMD with the average BMD of young adults.
|T-score||What it means|
|-1 and above||Normal|
|-2.5 to -1||Osteopenia, or low bone mass|
|Less than -2.5||Osteoporosis|
|Less than -2.5 and a fracture||Severe osteoporosis|