Reduced Fracture Risk and Increased Bone Density in women with postmenopausal osteoporosis

TYMLOS Reduced Fracture Risk and Increased Bone Density

In a clinical trial, women taking TYMLOS were compared with women taking a placebo (an injection that did not contain any medication) for 18 months. The study showed that at 18 months, women taking TYMLOS had:

Lower risk of having a spinal fracture

86-percent

Women taking TYMLOS had an 86% lower chance of getting a spinal fracture than those on placebo.

(0.6% of women taking TYMLOS had a fracture vs 4.2% taking placebo)

Lower risk of having fractures in other bones*

43-percent

Compared with placebo, women taking TYMLOS had a 43% lower risk of non-spinal fractures.

(2.7% of women taking TYMLOS had a fracture compared to 4.7% of women taking placebo)

*Fractures of the breast bone, kneecap, toes, fingers, skull and face, and those associated with high trauma were not included.

Increased bone density

bmd-graphic

Women taking TYMLOS had significant increases in bone mineral density (BMD) in the spine and hip, compared with women taking placebo.

At the start of the trial, women had the following average T-scores:

  • Lumbar spine (lower back): -2.9
  • Femoral neck (the area just below the ball joint of the hip): -2.1
  • Total hip: -1.9

Women had the following average T-scores at 18 months:

  • Lumbar spine (lower back): -2.1
  • Femoral neck (the area just below the ball joint of the hip): -1.96
  • Total hip: -1.63

Thank you to our participants

To everyone who participated in our clinical trials—from patient volunteers to doctors and nurses—thank you for your contributions that helped make this treatment available to women with postmenopausal osteoporosis!

What is the most important information I should know about TYMLOS?

TYMLOS may cause serious side effects including: Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more

What is the most important information I should know about TYMLOS?

TYMLOS may cause serious side effects including: Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more

What is the most important information I should know about TYMLOS?

  • Possible bone cancer (osteosarcoma). During animal drug testing, TYMLOS caused some rats to develop a bone cancer called osteosarcoma. It is not known if people who take TYMLOS will have a higher chance of getting osteosarcoma...Read more